According to the World Health Organization (WHO), worldwide obesity has nearly doubled since 1980. Researchers have discovered that the most startling cause for the increasing obesity epidemic is diet induced addiction to foods. Scientists have discovered that certain highly palatable foods disrupt the smooth functioning of the same brain-reward-pathways as cocaine and heroin. Overeating affects many of the bodies systems. Functional MRI scans performed on two patients with congenital deficiencies of the food satiety signal (Leptin) revealed the fundamental role this food signaling hormone plays in switching off the desire for food. The word Leptin is derived from the Greek word (Leptos) which means thin. Leptin is released after meals to enhance the satiety signals that diminish perception for food. Researchers have discovered that hormones like Leptin are altered in obese patients and thus they are less responsive to its signaling capacity. Food is the life bridge for our well-being, and what we intake for the normal functioning of our bodies really needs to be examined if we’re going avoid the deleterious effects of overeating. World Health Organization Obesity and overweight Fact sheet N°311 Updated March 2013 Leptin signaling and Obesity Lili A. Barouch, MD, Johns Hopkins University, 720 Rutland Ave, Ross 1050, Baltimore, MD 21205 Science 7 September 2007: Vol. 317 no. 5843 pp. 1355DOI:10.1126/science.1144599 Farooqi IS, Bullmore E, Keogh J, Gillard J, O'Rahilly S, Fletcher PC LEPTIN REGULATES STRIATAL REGIONS AND HUMAN EATING BEHAVIOR Nature Neuroscience 13, 635–641 (2010) doi:10.1038/nn.2519 Received 29 December 2009 Accepted 16 February 2010 Published online 28 March 2009 July 2010 Paul M Johnson & Paul J Kenny Bellisari, A. (2008), Evolutionary origins of obesity. Obesity Reviews, 9: 165–180. doi: 10.1111/j.1467-789X.2007.00392.x
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